Dr. Avideh Motmaen-Far, Osteopath D.O./Radio koocheh
GHR-15, is a product available through the Internet in capsule and powder form as a human growth hormone (HGH) supplement. The company promoting this product suggests it can cure or help prevent a variety of diseases, including cancer, diabetes, arthritis, heart disease, and multiple sclerosis. A few weeks ago, a team of physicians at Saint Louis University discovered that a compound acting in the opposite way as the growth hormone reverse some signs of aging and the growth hormone given to middle aged and older people may be hazardous. This new finding is very important because some older adults were taking growth hormone thinking that this fountain of youth would revitalize them.
Growth hormone (Somatotropin) is a protein synthesized and secreted by somatotrophs cells in the pituitary gland. This hormone has two distinct types of effects. It stimulates the liver to produce IGF-1 that stimulates the proliferation of chondrocytes (cartillage cells) and myoblasts (muscles cells), resulting in both bone growth and muscle growth. Growth hormone has also an important effect on proteins, lipids and carbohydrates metabolism.
Production of growth hormone is modulated by stress, exercise, nutrition, sleep and growth hormone itself. However, two hypothalamic hormones and one hormone from the stomach control its production. Growth hormone-releasing hormone (GHRH) is a hypothalamic peptide that stimulates both synthesis and secretion of growth hormone. Somatostatin (SS) is a peptide produced by several tissues in the body, specially the hypothalamus. It inhibits growth hormone release in response to GHRH and to other stimulatory factors such as low concentration of glucose in blood. Ghrelin is a peptide hormone secreted from the stomach which binds to receptors on somatotrophs and potently stimulates secretion of growth hormone. Growth hormone secretion is also part of a negative feedback loop involving IGF-1. High blood levels of IGF-1 lead to decreased secretion of growth hormone. It not only directly suppress the somatotroph, but also stimulates release of somatostatin from the hypothalamus. Basically, the concentration of growth hormone in blood is very low, but the most intense period of growth hormone release is shortly after the onset of deep sleep in children and young adults.
Excessive growth hormone secretion cause Giantism that begins in young children or adolescents. Giantism is a very rare condition that results from a tumour of somatotropes. One of the most famous giants was a man who weighed 8.5 pounds at birth, but by 5 years of age was 5 feet 4 (160cm) inches tall. As an adult he reached 8 feet 11(272 cm) inches in height and died at age 22. Excessive secretion of growth hormone in adults cause Acromegaly which results usually from a benign pituitary tumour. Clinical signs of acromegaly include overgrowth of extremities, soft-tissue swelling, abnormalities in jaw structure and cardiac disease. The growth hormone deficiency in children causes growth failure and short stature. It can also cause delayed sexual maturity.
Basically, the concentration of growth hormone in blood is very low, but the most intense period of growth hormone release is shortly after the onset of deep sleep in children and young adults
As a drug, the hGH is taken as an injection. It has been used since the 1950s to help stunted children grow normally. It is also given to AIDS patients to reverse muscle wastage and to adults with growth hormone deficiency. It stimulates muscle growth and helps reduce body fat. It also allows athletes to recover faster from strenuous training. Swimmers athletes mostly used to use this drug and it was undetectable until WADA recently devised a test for it. As a result, no athlete was ever caught using hGH prior to the new test being developed. Human growth hormone therapy has not been proven to be effective via oral treatments, therefore people taking GHR-15 are not likely to experience any therapeutic benefits. Health Canada cautions against the self-diagnosis or self-treatment of serious diseases and advises Canadians that GHR-15 is not approved as a treatment for any of these diseases. GHR-15 can also cause hyperthyroidism, which can lead to increased heart rate, elevated blood pressure, abnormal heart rhythms, excessive sweating, hand tremors, nervousness and anxiety, difficulty sleeping, weight loss despite increased appetite, increased activity level despite fatigue and weakness, and frequent bowel movements, occasionally with diarrhea.
In a recent study, scientists of the divisions of geriatric medicine and endocrinology at Saint Louis University School of Medicine, studied the compound MZ-5-156, a growth hormone-releasing hormone (GHRH) antagonist. They found that MZ-5-156 had positive effects on oxidative stress in the brain, improves cognition, telomerase activity (the actions of an enzyme which protects DNA material) and life span, and decrease tumour activity. This compound inhibited several human cancers such as prostate, breast, brain and lung cancers. It also had positive effects on learning, and was linked to improvements in short-term memory. Dr.William A. Banks, M.D., the lead study author said that antagonists of growth hormone-releasing hormone have beneficial effects on aging.
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