Saturday, 18 July 2015
26 January 2021
Koocheh Salamati – Leptin resistance and inflammation

”weight loss”

2010 October 16

Dr. Avideh Motmaen-far, Osteopath D.O./Radio Koocheh

You have probably already heard me talking about Leptin many times. Leptin is the first adipokin known to man. Dr. Geoffrey Friedman discovered in 1994 that the fat cells of a genetically obese mice failed to produce Leptin. Leptin is a hormone produced by fat cells that stimulates the metabolism and decrease the appetite. Leptin functions as a negative feedback. In mices, increase in weight leads to an increase in Leptin production which suppresses the appetite and stimulates fat burning. This process of self-correction is called homeostasis. But the chronically overweight humans are not Leptin deficient, they just seem to be resistant to Leptin. Weight loss is very difficult if not impossible with Leptin Resistance.

Another adipokines known to man is Adiponectin. It is a fat produced hormone that curbs appetite and stimulates fat burning but unlike Leptin, chronically overweight people suffer from an Adiponectin deficiency. When food is not available and fat stores drop, level of Adiponectin rises, helping muscle cells to take more sugar from the blood and burn fat as fuel. As fat stores increase, Adiponectin’s level drop and the burning of fat as fuel becomes less complete. It’s a process that allows the body to store fat in times of plenty.

Almost all the theories about weight loss especially those based on eating less and exercising more have failed to maintain a healthy body weight once people have achieved the ideal weight. May be the only way the science can help us undo the damage caused by technology is to understand Leptin Resistance. However, of all the theories attempting to combat Leptin Resistance the  existing proven link between obesity, Leptin and inflammation might be the key.

Since the ancient Greeks, inflammation has always been thought to produce symptoms such as redness, heat, swelling and pain. In the Twentieth Century, scientists have discovered the chemical basis of Inflammation. Today, inflammation is considered as a chemical state that can exist in all or/and part of your body without necessarily showing symptoms. Its presence is determined by measuring the levels of inflammatory chemicals in the inflamed tissue, or in a blood work. These chemicals cause serious damages to cells. They are called ”mediators of inflammation”. Many adipokines including Leptin and Adiponectin are mediators of inflammation. The more fat stored in your body, the higher the level of these mediators and the greater the level of inflammation.

However, of all the theories attempting to combat Leptin Resistance the  existing proven link between obesity, Leptin and inflammation might be the key

For a long time, being overweight was associated with osteoarthritis because Doctors used to  think that being heavy increases the wear and tear on your knee joints. But recent research has shown that it is Leptin produced by fat in the joints that causes inflammation. Leptin also triggers the production of an anti-inflammatory chemical called TGF-beta (transforming growth factor-beta). TGF-beta is part of a negative feedback loop to damp inflammation. But one of the effects of TGF-beta is to stimulate the growth of bone, in this case producing the bony overgrowth characteristic of osteoarthritis.

Inflammation and fat share a complex relationship. Inflammation raises also the level of insulin and cortisol, two hormones that cause your body to make more fat. Because high Insulin level prevents the breakdown of fat and Cortisol causes fat cells to grow.

«نوشته فوق می تواند نظر نویسنده باشد و الزامن نظر رادیو کوچه نیست»


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